Departments

St John's Medical College

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Dr Sidharth K. Totadri
Designation :Associate Professor
Department: Paediatric Haematology, Oncology & Bone Marrow Transplant
Email: sidharth.totadri@stjohns.in


MBBS, MD Pediatrics, DM Pediatric Hematology Oncology (PGIMER, Chandigarh), Fellowship in Pediatric Bone Marrow Transplant and CAR-T cell therapy (NH Bengaluru)

1. Indian Academy of Pediatrics (IAP)
2. Pediatric Hematology Oncology Chapter of IAP
3. INPHOG – Research Organisation of IAP PHO
4. Indian Society of Hematology and Blood Transfusion
4. International Society of Pediatric Oncology

A. Indexed journals
1. Antonisamy N, Boddu D, John R, Korrapolu RSA, Balasubramanian P, Arunachalam AK, Joseph LL, Srinivasan HN, Mathew LG, Totadri S. The Outcome of Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Experience from a Referral Center in South India. Indian J Hematol Blood Transfus. 2024 Jan;40(1):61-67. doi: 10.1007/s12288-023-01684-9. Epub 2023 Aug 9.

2. Totadri S, Bansal D, Donaldson SS, Binitie O, Teot L, Gupta AA, Oberoi S. Common queries in managing rhabdomyosarcoma in low- and middle-income countries: An Indo-North American collaboration. Pediatr Blood Cancer. 2023 Nov;70(11):e30616. doi: 10.1002/pbc.30616. Epub 2023 Aug 13.

3. Korrapolu RSA, Boddu D, John R, Antonisamy N, Geevar T, Arunachalam AK, Joseph LL, Srinivasan HN, Mathew LG, Totadri S. What happens to children with acute lymphoblastic leukemia in low- and middle-income countries after relapse? A single-center experience from India. Pediatr Hematol Oncol. 2023;40(5):475-484.

4. Joseph LL, Srinivasan HN, Robert M, Boddu D, John R, Mathew LG, Totadri S.* The Nutritional Trajectory of Children with Acute Lymphoblastic Leukemia: A 10-Year Follow up Study from a Referral Center in South India. Nutr Cancer. 2022 Nov 29:1-7.

5. Cherian T, John R, Joseph LL, Srinivasan HN, Boddu D, Geevar T, Mathew LG, Totadri S.* Complete Peripheral Blast Clearance is Superior to the Conventional Cut-Off of 1000/µL in Predicting Relapse in Pediatric Pre-B Acute Lymphoblastic Leukemia. Indian J Hematol Blood Transfus. 2021 Jul;37(3):366-371.

6. Joseph LL, Boddu D, Srinivasan HN, Regi SS, Antonisamy B, John R, Mathew LG, Totadri S.* Postchemotherapy tumor volume as a prognostic indicator in Wilms tumor: A single-center experience from South India. Pediatr Blood Cancer. 2021 Nov 22:e29454. doi: 10.1002/pbc.29454.

7. Totadri S, Srinivasan HN, Joseph LL, Boddu D, Suresh Kochath P, Moorthy M, Mathew LG, John RR. The Unique Balancing Act of Managing Children With Cancer and COVID-19 Infection: A Single Center Experience From South India. J Pediatr Hematol Oncol. 2021 Mar 23. doi: 10.1097/MPH.0000000000002148

8. Totadri S, Srinivasan HN, Joseph LL, Boddu D, Mathew LG, John R. A single assessment of methotrexate levels at 42 hours permits safe administration and early discharge in children with lymphoblastic lymphoma and leukemia receiving high-dose methotrexate. Pediatr Hematol Oncol. 2021;38:434-443.

9. Totadri S.* Slow and Steady Keeps Them in the Race: Metronomic Therapy in Children With Cancer. Indian Pediatr. 2020 Jun 15;57(6):501-502.

10. Totadri S, Bansal D, Rao KLN, Jain R, Saxena AK, Kapoor R, Samujh R, Trehan A. Challenges in the management of localized Ewing sarcoma in a developing country. Pediatr Hematol Oncol. 2020;37:610-619.

11. Totadri S, Thipparapu S, Aggarwal R, Sharma M, Naseem S, Jain R, Trehan A, Malhotra P, Varma N, Bansal D. Imatinib-Induced Hypogammaglobulinemia in Children and Adolescents with Chronic Myeloid Leukemia. Pediatr Hematol Oncol. 2020;37:539-544. 12. Jain R, Hans R, Totadri S, Trehan A, Sharma RR, Menon P, Kapoor R, Saxena AK, Mittal BR, Bhatia P, Kakkar N, Srinivasan R, Rajwanshi A, Varma N, Samujh R, Marwaha N, Bansal D. Autologous stem cell transplant for high-risk neuroblastoma: Achieving cure with low-cost adaptations. Pediatr Blood Cancer. 2020;67:e28273. doi: 10.1002/pbc.28273.

13. Bhatia P, Totadri S, Singh M, Sharma P, Trehan A, Bansal D, Jain R, Varma N, Sachdeva MS, Patra N. PEST domain NOTCH mutations confer a poor relapse free survival in pediatric T-ALL: Data from a tertiary care centre in India. Blood Cells Mol Dis. 2020;82:102419. doi: 10.1016/j.bcmd.2020.102419.

14. Sah RR, Ray S, Bhatia P, Dhir SK, Totadri S, Kumar N, Kumar P. A Case of Novel GATA-1 Mutation-positive Transient Abnormal Myelopoiesis With Life-threatening Complications in a Neonate With Down Syndrome. J Pediatr Hematol Oncol. 2021;43:e292-e295.

15. Totadri S, Trehan A, Saxena AK. Swollen digits: an unusual manifestation of childhood acute lymphoblastic leukaemia. J Pediatr: X. 2019;1:100002

16. Totadri S, Trehan A, Mahajan D, Viani K, Barr R, Ladas EJ. Validation of an algorithmic nutritional approach in children undergoing chemotherapy for cancer. Pediatr Blood Cancer. 2019;66:e27980. doi: 10.1002/pbc.27980.

17. Totadri S, Trehan A, Kaur A, Bansal D. Effect of socio-economic status & proximity of patient residence to hospital on survival in childhood acute lymphoblastic leukaemia. Indian J Med Res 2019;149:26-33.

18. Totadri S, Bansal D. Staging of acute leukemia based on central nervous system involvement alone: Is it appropriate? Pediatr Blood Cancer. 2019;66:e27730.

19. Totadri S, Sundersingh S, Natarajan R, Seshadri RA, Radhakrishnan V. Gastrointestinal mucormycosis in a child with acute lymphoblastic leukemia: An uncommon but ominous complication. Indian J Cancer. 2018;55:304-305.

20. Singh M, Bhatia P, Shandilya JK, Rawat A, Varma N, Sachdeva MS, Trehan A, Bansal D, Jain R, Totadri S. Low Expression of Leucocyte Associated Immunoglobulin Like Receptor-1 (LAIR-1/CD305) in a Cohort of Pediatric Acute Lymphoblastic Leukemia Cases. Asian Pac J Cancer Prev. 2018;19:3131-3135.

21. Totadri S, Bansal D. Invasive Fungal Disease in Children with Acute Leukemia: The Elusive Culprit. Indian J Pediatr. 2018;85:1059-1060.

22. Totadri S, Bansal D. Addressing Psychosocial Support in Children with Cancer in Low- and Middle-Income Countries. Indian J Pediatr. 2018. doi:10.1007/s12098-018-2774-1.

23. Totadri S, Radhakrishnan V, Ganesan TS, et al. Can Radiotherapy Be Omitted in Children With Hodgkin Lymphoma Who Achieve Metabolic Remission on Interim Positron Emission Tomography? Experience of a Tertiary Care Cancer Referral Center. Journal of Global Oncology 2018;4:1-7.

24. Totadri S, Singh M, Trehan A, Varma N and Bhatia P. Keeping PACE with Ph Positive to Ph-Like Detection in B-Lineage Acute Lymphoblastic Leukemia: A Practical and Cost Effective (PACE) Approach in a Resource Constrained Setting. Indian J Hematol Blood Transfus 2018. https://doi.org/10.1007/s12288-018-0997-y.

25. Totadri S, Bansal D, Trehan A, Khadwal A, Bhatia A, Sodhi KS, Bhatia P, Jain R, Das R and Khandelwal N. Hepatic and Cardiac Iron-load in Children on Long-term Chelation with Deferiprone for Thalassemia Major. Indian Pediatr 2018;55:573-575.

26. Bansal D and Totadri S. Comprehensive Hemophilia Management in India – Miles to Go Before We Sleep. Indian Pediatr 2018;55: 559-560. 27. Totadri S, Munikoty V, Singh U, Srinivasan R, Trehan A, Jain R, Kakkar N, Saxena AK, Rajwanshi A, Bansal D. Is a diagnostic lumbar puncture indicated in intraocular retinoblastoma? Indian J Pathol Microbiol. 2018;61:201-203.

28. Totadri S, Trehan A, Bhattacharya A, Bansal D, Attri SV, Srinivasan R. Chylothorax in children with cancer: A milky predicament. Indian J Cancer. 2017;54:691-694

29. Totadri S, Trehan A, Bansal D, Jain R. Sinusoidal Obstruction Syndrome during Treatment for Wilms' Tumor: A Life-threatening Complication. Indian J Med Paediatr Oncol. 2017;38:447-451.

30. Totadri S, Bhatia P, Sreedharanunni S. RUNX1-RUNX1T1-positive acute myeloid leukaemia presenting as bilateral proptosis and multiple cranial nerve palsy. BMJ Case Rep. 2017;2017. doi: 10.1136/bcr-2017-221402.

31. Totadri S, Bansal D, Bal A, Menon P. Bulky Pelvic Hodgkin Lymphoma in a Prepubertal Girl. Indian J Med Paediatr Oncol. 2017;38:226-227. 32. Bansal D, Totadri S, Chinnaswamy G, Agarwala S, Vora T, Arora B, Prasad M, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Bakhshi S. Management of Neuroblastoma: ICMR Consensus Document. Indian J Pediatr. 2017;84:446-455.

33. Radhakrishnan V, Kumar P, Totadri S, Ganesan P, Selvaluxmy G, Ganesan T, Dhanushkodi M, Sagar T. Pediatric nasopharyngeal carcinoma: Experience from a tertiary cancer center in India. Indian J Cancer. 2016;53:377-380.

34. Radhakrishnan V, Reddy P, Totadri S, Sundersingh S, Sagar TG. Multiple Myeloma in an 8-Year-Old Child With HIV Infection. J Pediatr Hematol Oncol. 2017;39:77.

35. Bommannan K, Totadri S, Sachdeva MU, Naseem S, Trehan A, Varma N. p210 BCR-ABL1 positive pediatric B-lineage acute lymphoblastic leukemia presenting with hypercalcemia. Leuk Lymphoma. 2017;58:501-502.

36. Totadri S, Radhakrishnan V, Raja A, Sagar TG. Chikungunya Fever With Seizures, Myocarditis, and Severe Thrombocytopenia in a Child With Osteosarcoma. Pediatr Blood Cancer. 2016;63:1687.

37. Totadri S, Trehan A, Srinivasan R, Bansal D, Bhatia P. Do traumatic lumbar punctures lead to greater relapses in acute lymphoblastic leukemia? Experience at a university hospital in India. Indian J Cancer. 2015;52:300-3.

38. Chougule A, Srivastava S, Totadri S, Srinivasan R, Trehan A. Nodal Langerhans cell histiocytosis with prominent eosinophilic emperipolesis. Diagn Cytopathol. 2015;43:1000-2.

39. Totadri S, Bansal D, Trehan A, Srinivasan R, Varma N, Kakkar N, Saxena AK, Bhatia P. The 5-Year EFS of Multisystem LCH With Risk-Organ Involvement Is Suboptimal: A Single-center Experience From India. J Pediatr Hematol Oncol. 2016;38:e1-5.

40. Totadri S, Bansal D, Bhatia P, Attri SV, Trehan A, Marwaha RK. The deferiprone and deferasirox combination is efficacious in iron overloaded patients with β-thalassemia major: A prospective, single center, open-label study. Pediatr Blood Cancer. 2015;62:1592-6.

41. Trehan A, Totadri S, Gautam V, Bansal D, Ray P. Invasive bacterial infections in a pediatric oncology unit in a tertiary care center. Indian J Cancer. 2014;51:428-31.

42. Kapoor A, Savardekar A, Totadri S, Trehan A, Salunke P. Delayed intracranial hemorrhage following head injury in hemophilia B patient. Indian J Pediatr. 2015;82:195-6.

43. Bansal D, Totadri S. Common hematological disorders in children. Indian J Pediatr. 2014;81:42-50.

44. Khurana S, Mewara A, Verma S, Totadri S. Central nervous system infection with Acanthamoeba in a malnourished child. BMJ Case Rep. 2012 Oct 24;2012. doi: 10.1136/bcr-2012-007449.

B. Chapters in Textbooks
1. Totadri S. Langerhans cell histiocytosis. In: PGI textbook of laboratory and clinical hematology. Ed. Krishnan K. Bhalani Publishing House, Mumbai, 2023, Volume 3, Section 10, Chapter 186.

2. Totadri S, Bansal D. Recent Advances in Thalassemia. In: Hot Topics in Pediatrics. 1st edition. Ed. Kabra S.K. The Indian Journal of Pediatrics, N Delhi, 2019, pp 265-81.

3. Totadri S, Bansal D. Childhood ITP: Whats new?. In: Hot Topics in Pediatrics. 1st edition. Ed. Kabra S.K. The Indian Journal of Pediatrics, N Delhi, 2019, pp 241-64.

4. Totadri S, Bansal D. Thrombotic Disorders. In: Indian Academy of Pediatrics - PG textbook of Pediatrics. 2nd edition. Eds. Gupta P, Menon PSN, Ramji S, Lodha R. Jaypee Brothers Medical Publishers (P). Ltd, N Delhi, 2018, pp 1929-37.

5. Trehan A, Totadri S. Thrombocytopenia. In: Indian Academy of Pediatrics - PG textbook of Pediatrics. 2nd edition. Eds. Gupta P, Menon PSN, Ramji S, Lodha R. Jaypee Brothers Medical Publishers (P). Ltd, N Delhi, 2018, pp 1909-315.

6. Bansal D, Totadri S. Common Hematological Disorders in Children. In: Pediatrics in General Practice. Ed Pandhi BS. Indian journal of Pediatrics, New Delhi 2016, pp 179-93.

7. Bansal D, Totadri S. Revision of chapter: Principles of Pediatric Oncology. In: Practical Pediatric Oncology. 3rd ed. Ed: G Kapoor. Pediatric Hematology Oncology Chapter of Indian

Planned projects:
1. Cultural competence in managing patients from varying linguistic and ethnic backgrounds
2. Evolution of multidrug-resistant organisms and changing use of antimicrobials in children receiving chemotherapy and undergoing transplant

Thalassemia, rare hemolytic anemias, hemophilia, rare bleeding disorders, pediatric leukemias, solid malignancies in children: neuroblastoma, Wilms tumor, rhabdomyosarcoma, germ cell tumor, hepatoblastoma, brain tumors and rare tumors, bone marrow transplant

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